Magnesium citrate anhydrous, nonahydrate n dodecahydrate Manufacturers

Anmol Chemicals is the pioneer manufacturers of Citrates, Pharmaceutical Excipients Fragrance Food & Flavor chemicals in India. We offer Halal and Kosher Citrates made in an ISO9001, ISO22000 (FSSC22000), GLP and cGMP certified facility. Our group has several manufacturing facilities spread across the world, supported by toll manufacturers and representatives in UAE, Europe, Africa, USA, China and has several associated manufacturing facilities spread across India. All the Information on Physics, Chemistry, Applications, Uses and Technology on Manufacture of Magnesium citrate anhydrous, nonahydrate & dodecahydrate is in these pages.

The units have one or more of the certifications like FDA GMP, ISO 9001, ISO 22000, HACCP, REACH, Kosher & Halal

Magnesium citrate anhydrous, nonahydrate & dodecahydrate BP USP Ph Eur IP FCC Food grade Manufacturers, also Microencapsulated Magnesium Citrate

Magnesium citrate CAS Number 3344-18-1 & 153531-96-5, Molecular Weight 451.11, EINECS EC Number 222-093-9, Chemical Formula C12H10Mg3-O14

Magnesium citrate
Commercial Pure Crystals, Anhydrous, Nonahydrate & Dodecahydrate &
IP BP Ph Eur USP FCC Food Grades

Specifications of Magnesium Citrate USP
C12H10Mg3O14 451.11
1,2,3-Propanetricarboxylic acid, hydroxy-, magnesium salt (2:3).
Magnesium citrate (3:2) CAS Number3344-18-1.

Magnesium Citrate contains not less than 14.5 percent and not more than 16.4 percent of magnesium (Mg), calculated on the dried basis.

Labeling: Magnesium Citrate that loses not more than 2.0% of its weight in the test for Loss on drying may be labeled as Anhydrous Magnesium Citrate.
Identification:
A: A solution (10 mg per mL) responds to the tests for Magnesium.
B: A solution (80 mg per mL) responds to the tests for Citrate.
pH: between 5.0 and 9.0, in a suspension (50 mg per mL).
Loss on drying: Dry 1 g in a mechanical convection oven at 135 for 16 hours, then to constant weight: it loses not more than 29% of its weight, except that where it is labeled as anhydrous, it loses not more than 2.0% of its weight.
Chloride: A 300-mg portion shows no more chloride than corresponds to 0.20 mL of 0.020 N hydrochloric acid (0.05%).
Sulfate: A 100-mg portion shows no more sulfate than corresponds to 0.20 mL of 0.020N sulfuric acid (0.2%).
Arsenic: 3 6g per g.
Heavy metals: Dissolve 0.4 g in 25 mL of water, and proceed as directed for Test Preparation, except to use glacial acetic acid to adjust the pH: the limit is 50 6g per g.
Iron— Boil 50 mg with 5 mL of 2 N nitric acid for 1 minute. Cool, dilute with water to 45 mL, add 2 mL of hydrochloric acid, and mix: the limit is 200 6g per g.
Limit of calcium: the limit is 1.0%, calculated on the dried basis. (The method is described in Magnesium Carbonate & Magnesium Citrate Monograph.
Assay: Weigh accurately about 400 mg of the substance, dissolve in 50 mL of water, add 20 mL of ammonia–ammonium chloride buffer TS and 0.1 mL of eriochrome black TS, and titrate with 0.05 M edetate disodium VS to a blue endpoint. Perform a blank determination, and make any necessary correction. From the volume of 0.05 M edetate disodium consumed, deduct the volume of 0.05 M edetate disodium corresponding to the amount of calcium in the portion of Magnesium Citrate taken, based on the amount of calcium found in the test for Limit of calcium. Each mg of calcium (Ca) is equivalent to 0.25 mL of 0.05 M edetate disodium. The difference is the volume of 0.05 M edetate disodium consumed by the magnesium. Each mL of 0.05 M edetate disodium is equivalent to 1.215 mg of magnesium (Mg).

Anhydrous Magnesium Citrate BP Ph Eur Grade Specifications
Mg3(C6H5O7)2 --- 451.1 --- CAS Number 3344-18-1

DEFINITION
Trimagnesium bis(2-hydroxypropane-1,2,3-tricarboxylate).
Content: 15.0 per cent to 16.5 per cent of Mg (dried substance).

CHARACTERS
Appearance: White or almost white, fine, slightly hygroscopic powder.
Solubility: Soluble in water, practically insoluble in ethanol (96 per cent). It dissolves in dilute hydrochloric acid.

IDENTIFICATION
A. It gives the reaction of citrates.
B. It gives the reaction of magnesium.
C. pH (see Tests).
D. Loss on drying (see Tests).

TESTS
Solution S: Dissolve 5.0 g in carbon dioxide-free water R, heating at 60C, cool and dilute to 100 mL with the same solvent.
Appearance of solution: Solution S is not more opalescent than reference suspension and not more intensely coloured than reference solutions.
pH: 6.0 to 8.5 for solution S.
Oxalates: Maximum 280 ppm.
Sulfates: Maximum 0.2 per cent.
Calcium: Maximum 0.2 per cent.
Iron: Maximum 100 ppm.
Heavy metals: Maximum 10 ppm.
Loss on drying: Maximum 3.5 per cent, determined on 1.000 g by drying in an oven at 180±10C for 5 h.

Magnesium Citrate Dodecahydrate BP Ph Eur Grade
Mg3(C6H5O7)2,xH2O --- 451.1 (anhydrous substance)
with x ≈ 12

DEFINITION
Trimagnesium bis(2-hydroxypropane-1,2,3-tricarboxylate) dodecahydrate.
Content: 15.0 per cent to 16.5 per cent of Mg (dried substance).

CHARACTERS
Appearance: White or almost white, fine powder.
Solubility: Sparingly soluble in water, practically insoluble in ethanol (96 per cent). It dissolves in dilute hydrochloric acid.

IDENTIFICATION
A. It gives the reaction of citrates.
B. It gives the reaction of magnesium.
C. Loss on drying (see Tests).

TESTS
Solution S: Dissolve 2.5 g in 15 mL of dilute hydrochloric acid with heating. Cool and dilute to 100 mL with distilled water.
Appearance of solution: Solution S is clear and not more intensely coloured than reference solution.
pH: 6.0 to 8.5.
Oxalates: Maximum 280 ppm.
Sulfates: Maximum 0.2 per cent.
Calcium: Maximum 0.2 per cent.
Iron: Maximum 100 ppm.
Heavy metals: Maximum 10 ppm.
Loss on drying: 29.0 per cent to 36.0 per cent, determined on 1.000 g by drying in an oven at 180±10C for 5 h.

Magnesium Citrate Nonahydrate BP Ph Eur Grade
Mg3(C6H5O7)2,9H2O --- 613 --- CAS Number 153531-96-5

DEFINITION
Trimagnesium bis(2-hydroxypropane-1,2,3-tricarboxylate) nonahydrate.
Content: 15.0 per cent to 16.5 per cent of Mg (dried substance).

CHARACTERS
Appearance: White or almost white, fine powder.
Solubility: Sparingly soluble in water, practically insoluble in ethanol (96 per cent). It dissolves in dilute hydrochloric acid.

IDENTIFICATION
A. It gives the reaction of citrates.
B. It gives the reaction of magnesium (2.3.1).
C. Loss on drying (see Tests).

TESTS
Solution S: Dissolve 2.5 g in 15 mL of dilute hydrochloric acid with heating. Cool and dilute to 100 mL with distilled water.
Appearance of solution: Solution S is clear and not more intensely coloured than reference solution.
pH: 6.0 to 8.5.
Oxalates: Maximum 280 ppm.
Sulfates: Maximum 0.2 per cent.
Calcium: Maximum 0.2 per cent.
Iron: Maximum 100 ppm.
Heavy metals: Maximum 10 ppm.
Loss on drying: 24.0 to 28.0 per cent, determined on 1.000 g by drying in an oven at 180±10C for 5 h.

Magnesium citrate anhydrous, nonahydrate & dodecahydrate BP USP Ph Eur IP FCC Food grade Manufacturers:

Anmol Chemicals
S-8, SARIFA MANSION, 2ND FLANK ROAD, CHINCHBUNDER, MUMBAI 400009, INDIA
TEL: (OFFICE) 91-22-23770100, 23726950, 23774610, 23723564 - FAX: 91-22-23728264

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