Triethyl Citrate USP NF BP Ph Eur FCC Food Grade Manufacturers

Anmol Chemicals is the pioneer manufacturers of Citrates, Pharmaceutical Excipients Fragrance Food & Flavor chemicals in India. We offer Halal and Kosher Citrates made in an ISO9001, ISO22000 (FSSC22000), GLP and cGMP certified facility. Our group has several manufacturing facilities spread across the world, supported by toll manufacturers and representatives in UAE, Europe, Africa, USA, China and has several associated manufacturing facilities spread across India. All the Information on Physics, Chemistry, Applications, Uses and Technology on Manufacture of Triethyl Citrate is in these pages.

The units have one or more of the certifications like FDA GMP, ISO 9001, ISO 22000, HACCP, REACH, Kosher & Halal

Triethyl Citrate USP NF BP Ph Eur FCC Food Grade Manufacturers

Triethyl Citrate CAS Number: 77-93-0, EINECS EC Number: 201-070-7, Molecular Formula: C12H20O7 or HOC(COOC2H5)(CH2COOC2H5)2, Molecular Weight: 276.28, FEMA Number: 3083

General Properties and Specifications of Triethyl Citrate:
Appearance: Clear colorless or almost colorless oily liquid.
Assay: 99% minimum.
Melting point: -55C
Boiling point: 294C
Relative density: 1.14
Solubility: Soluble in water, miscible with ethanol (96 per cent).

DEFINITION
Triethyl Citrate contains NLT 99.0% and NMT 100.5% of C12H20O7 , calculated on the anhydrous basis.

IDENTIFICATION
A. Infrared Absorption
B. The retention time of the major peak of the Sample solution corresponds to that of a similar preparation of USP Triethyl Citrate RS, as obtained in the Assay.
ASSAY
To pass the test by Chromatography.
Acceptance criteria: 99.0%–100.5% on the anhydrous basis
Specific Gravity: 1.135–1.139
Refractive Index: 1.439–1.441
Acidity:
Neutralized isopropyl alcohol: To a suitable quantity of isopropyl alcohol add 2–3 drops of bromothymol blue and just sufficient 0.10 N sodium hydroxide dropwise to produce a faint blue color. [Note— Prepare Neutralized isopropyl alcohol just prior to use.]
Sample solution: 32.0 g of Triethyl Citrate in 30 mL of Neutralized isopropyl alcohol
Analysis: Add bromothymol blue. Titrate with 0.10 N sodium hydroxide to a faint blue endpoint.
Acceptance criteria: NMT 1.0 mL of 0.10 N sodium hydroxide is required.
Water Determination: NMT 0.25%
Packaging and Storage: Preserve in tight containers.

Specifications of Triethyl Citrate BP Ph Eur Grade:
C12H20O7 --- 276.3 --- CAS Number 77-93-0
Action and use: Excipient.

DEFINITION
Triethyl 2-hydroxypropane-1,2,3-tricarboxylate.
Content: 98.5 per cent to 101.0 per cent (anhydrous substance).

CHARACTERS
Appearance: Clear, viscous, colourless or almost colourless, hygroscopic liquid.
Solubility: Soluble in water, miscible with ethanol (96 per cent), slightly soluble in fatty oils.

IDENTIFICATION
First identification: A, B
Second identification: A, C, D
A. Refractive index (see Tests).
B. Infrared absorption spectrophotometry.
Comparison Ph. Eur. reference spectrum of triethyl citrate.
C. It gives the reaction of esters.
D. To 0.5 mL add 5 mL of ethanol (96 per cent) and 4 mL of dilute sodium hydroxide solution. Boil under reflux for about 10 min. 2 mL of the solution gives the reaction of citrates.

TESTS
Appearance: The substance to be examined is clear and not more intensely coloured than reference solution
Acidity: Dilute 10 g with 10 mL of previously neutralised ethanol (96 per cent), add 0.5 mL of bromothymol blue solution. Not more than 0.3 mL of 0.1 M sodium hydroxide is required to change the colour of the indicator to blue.
Refractive index: 1.440 to 1.446.
Related substances: To pass the test by Gas chromatography.
Limits:
-any impurity: for each impurity, maximum 0.2 per cent;
-total: maximum 0.5 per cent;
-disregard limit: 0.04 per cent.
Water: Maximum 0.25 per cent, determined on 1.000 g.
Sulfated ash: Maximum 0.1 per cent, determined on 1.0 g.

Specifications of Triethyl Citrate FCC Food Grade:
Ethyl Citrate
C12H20O7 Formula weight 276.29
INS: 1519 CAS Number 77-93-0

DESCRIPTION
Triethyl Citrate occurs as a practically colorless, oily liquid. It is slightly soluble in water but is miscible with alcohol and with ether.
Function: Solvent.

Anmol Chemicals
S-8, SARIFA MANSION, 2ND FLANK ROAD, CHINCHBUNDER, MUMBAI 400009, INDIA
TEL: (OFFICE) 91-22-23770100, 23726950, 23774610, 23723564 - FAX: 91-22-23728264

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